Parkinson’s disease (PD) is a progressive extrapyramidal neurodegerative disorder. Oxidative stress has been implicated in the etiology of parkinson’s disease (PD). The important biochemical features of PD, being profound deficit in dopamine (DA) content, reduced glutathione (GSH), enhanced activity of superoxide dismutase (SOD), enhanced lipid peroxidation (LPO) and nitric oxide (NO) in dopaminergic neurons resulting in oxidative stress, mitochondrial dysfunction and apoptosis. Rotenone-induced neurotoxicity is a well acknowledged preclinical model for studying PD in rodents as it produces selective dopamineric neuronal degeneration. The main objective of the present study was to evaluate the neuroprotective effect of Saussurea lappa on rotenone induced parkinsonism in rats. Male wistar rats weighing (150-200 g) were divided into 4 groups with (n=6) in each group. Group I: vehicle treated group, Group II: rotenone group, Group III and Group IV received low and high doses of Saussurea lappa extract all treatments were given for 11 days. On the 13th day behavioral tests were conducted and finally animals were sacrificed and the brain was dissected out for biochemical estimations and histopathology test. In the present study administration of rotenone for 11 days has significantly induced PD by behavioral alterations and biochemical alterarations. Treatment with high doses of Saussurea lappa improved behavioral alterations and biochemical studies revealed the role of Saussurea lappa in preventing the oxidative stress markers. Histopathological studies justified that, treatment with Saussurea lappa extract protected the dopaminergic neurodegeration in nigrostraital pathway.
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